Creating a Wiki for FoldIt is a big challenge, and one of the hardest parts about it is knowing what questions the players want answered. I thought I'd create this page so that people could ask questions, supply answers, and eventually those questions/answers could be spun off into pages of their own. So... feel free to ask and answer!

How is score calculated? Everything has energy. The less energetic the protein is, the higher your score! The score for most puzzles is the sum of the scores for each individual segment. Further, the score for each individual segment (which can be found by placing the mouse pointer over a segment, then pressing TAB) consists of the sum of the following elements:

  1. Clashing
  1. Packing
  1. Hiding
  1. Bonding
  1. Sidechain
  1. Reference

The overall score, segment score, or each element may be negative.

Can past announcements at Fold.It be accessed, after they have expired from the main page? They're found in their super-top-secret location here.

How well are we humans doing versus the computers, really? In CASP8 (2008), we did better than all the "fully automated computers, but about the same as the professional humans (helped by computers). But some caveats apply before drawing too many conclusions (see the link for details).

How well are we humans doing versus nature ? Could humans find a less energetic conformation than what is naturally occuring ? Or nature always makes the proteins take the shape of minimal energy ?

How do voids work? This is best covered in

Can i view my current Achievement Points somewhere? On your personnal page, click on show details then show progress on

How did you find all those proteins? I am not getting the source of it all. ;-) Let's say we have found a new protein: Amylase. First of all: how did you find it? Did you just examine a piece of tissue/blood/whatever and stumbled upon a new chain of amino acids? And second: at the time you discovered this new protein: why do you need to fold it? Didn't you find it already folded like it has to be in nature?

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