Ligand movementEdit

Moving the ligand can get extra points. It may take brute force. Pull and tug on it, or twist it around and let it settle back. Pulling gently on a sidechain can shake the ligand and let it find a new energy (and more points).

Additionally, a method used on some interface puzzles with only the ligands moveable was to band the ligand to the sidechains. The ligand's H-bonding atoms are banded to nearby sidechains that can H-bond with the ligand. This may take several strong bands. Once the ligand is banded in the place you want it to be, remove the bands, and wiggle, mutate, wiggle out. This method was used successfully on puzzle 37x ( If you know which one, please edit).

Tips for frozen puzzlesEdit

Occasionally there may be two separate proteins in a puzzle. Even if they are frozen, you can still move one of them. This may allow it to spring back and settle into a new position. See > Rock The Boat

Interface puzzlesEdit

On interface puzzles it is often good to set short bands radiating off into space. These can be set all around or all going just to one side. These bands are then disabled and wiggle all or wiggle backbone is turned on. Then rapidly enable and then disable the bands. This method shakes the backbone and can let it settle into a new shape.


Sidechains can be brought together or aligned by banding and pulling. Sometimes sheets can also be turned by pulling on the side chains.

An interesting way to get incremental fractions of a point is by sidechain tweaking. You start by freezing the whole protein, except for the sidechains. Then, pick out a good sidechain (ringed hydrophobics and proline are best), and gradually pull the sidechain in one direction. The score will rise, then drop, in the .01 point range. When the score drops, pull the sidechain the other way. Don't stay in one place too long. When you feel you have exhausted the potential of one particular sidechain, move around to another, and so on.

For the latest papers on Game Tips and Techniques see > The Foldit Labs

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