- Articles
2,937 results
-
Foldit Wiki
Foldit is an online citizen science game in which humans try to solve one of the hardest computational problems in biology: protein folding. You don't need to know anything about biology to play the -
Foldit Lua Functions
Note: This page is generated from the output of the help command in the Foldit client. Please don't make changes to this page. Changes may be overwritten when the page is regenerated. To add -
Lua Scripting Tutorial (Advanced)
Lua is the language used for recipes (also known as scripts or macros) in Foldit. See Lua Scripting for an overview and links to series of beginner scripting tutorials. This tutorial is for more experienced -
Simplified List of Lua Commands
Note: the commands (functions) described here are for Version 2 (V2) of the Foldit Lua Interface. The Version 1 equivalents are shown in parenthesis. See Simplified List of Lua Commands (V1) for the V1 version -
Design structures
In 2012, the Baker group published a paper "Principles for designing ideal protein structures” in Nature. This article is usually referred to as Koga& Koga in Foldit, after the lead authors. It's the basis -
Protein backbone
Protein backbone is what holds a protein together and gives it an overall shape (or tertiary structure). Compared to RNA and DNA backbone, protein backbone has a relatively simple chemical structure - a nitrogen atom, two -
Hydrogen bond
Hydrogen bonds help stabilize proteins. In Foldit, hydrogen bonds appears as blue-and-white spirals (or "candy canes") when the "Show bonds" is selected in the View Options menu. The strength of hydrogen bonds varies -
Campaign
The puzzles in the Campaign show you how to play Foldit. This special level shows you how to use many of the tools, and explains some of the key ideas, like Clashes, Voids, and Exposeds -
Coronavirus Spike Protein
The Coronavirus Spike Protein is found on the surface of a coronavirus. This protein allows the virus to bind to specific receptors on the surface of a human cell, the first step toward infecting the -
Amino Acids
Amino acids (also called segments or residues in Foldit) are the building blocks of proteins. Each amino acid has a unique sidechain, except for glycine. Each protein is identified by a unique sequence of amino -
IRC Set up - MIBBIT ( web based IRC)
Mibbit is a web based IRC client that can be used without having to download a program. It can be used with any operating system and browser with relative ease, just follow the simple instructions -
Disulfide Bridge
A disulfide bridge is a strong bond that can form between two cysteines. The strength of disulfide bridges helps stabilize a protein. Disulfide bridges are especially common in proteins that are secreted from cells. For -
Campaign/Flippin' Sheets
In this puzzle, the second sheet from the top has two hydrophobics with blotchy yellow exposeds on them. Madde's "Flippin' Sheets" video -
Rotamer
In proteins, the sidechain of an amino acid can take different positions. These positions are called rotamers. Foldit puzzles may also contain non-protein molecules called ligands. In some cases, small molecule ligands may have -
Sidechain
Sidechains are the shapes that stick out from the backbone of a protein. Some sidechains have only one position, but others can be "flipped" to multiple positions. In Foldit, you can click and drag on -
Campaign/Hydrophobic Disaster
Hydrophobic Disaster starts with one sheet sticking out the right. The sheet has three blotchy yellow exposed hydrophobics. At least five other hydrophobics are exposed in other parts of the protein. Loci's "Hydrophobic Disaster -
Campaign/Lock and Lower
In this puzzle, one sheet is pointing off into space. A group of three sheets is already bonded together. Another sheet is off to one side, connected to the out-of-line sheet by a -
Solved Foldit designs
The Foldit science team evaluates the results of design puzzles, and tests the most promising solutions in the lab. Several Foldit proteins have been successfully grown in the lab and then "solved" using X-ray -
Education mode
Education mode is a special version of Foldit intended for classroom use. Education mode is described in a Foldit post titled For Educators, which explains how to download and install the education mode version of -
Lua Error Handling
The pcall command The pcall command wraps a function call and catches any error that occurs during the function. The return values of pcall are either true, followed by the return values of the function -
Campaign/Inside the Pocket
In this puzzle, you'll use the Atom Selection tool to replace atoms in a small molecule ligand. You'll also change the bonds between atoms in the ligand. The first step is to find -
Campaign/Control Over Clashing
This puzzle starts out with a lot of clashes. Clashes tend to push the protein apart, breaking hydrogen bonds, opening up voids, and causing hydrophobic segments to become exposed. All these things are Bad. Madde -
Campaign/Lonely Sheets
This puzzle has two small sheets a long way apart. The two sheets should be bonded together, but just wiggling won't get them there. Madde's "Lonely Sheets" video -
Alpha carbon
The alpha carbon is the central point in the backbone of every amino acid. The alpha carbon (α-carbon or Cα) is what connects the amino group to the acid carboxyl group, giving amino acids -
Primary Structure
The primary structure of a protein is the sequence of amino acids that make up the protein. The primary structure is also called the primary sequence, amino acid sequence or AA sequence. The primary structure
Related Community
Marvel Database
comics
200K
Pages200K
Images1K
Videos
With more than 200,000 articles, the Marvel Database is the largest Marvel Comics encyclopedia ever written, as well as being the 5th largest FANDOM wiki. The database covers comics, characters, teams, games, TV shows and movies. Browse one of over…