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tokens' monocyte protein from Puzzle 1343.

88: Monocyte is a Foldit revisiting puzzle, originally presented as Puzzle 88: Monocyte in 2008.

The protein in this puzzle is from a human monocyte, a type of white blood cell.

The puzzle protein has 71 segments with the sequence:


The sequence is found in these Protein Data Bank entries:

  • 4R8I (chain A, offset 0)
  • 1DOL (chain A, offset 0)
  • 1DOK (chains A, B; offset 0)

The puzzle protein can have two disulfide bridges, identified in 4R8I as 11-36, and 12-52. The model in 4R8I omits the methionine which appears at segment 1 in the puzzle, so you must add one to the residue numbers in the PDB. Similarly, the model for 1DOL has the methionine as residue 0, so once again you must add one to get the Foldit segment number.

In recent visits to this puzzle, each bridge is awarded a bonus of 250 points.

The recipe Bridge Wiggle v 1.2.1 - Brow42 accepts the (corrected) bridges in this format:

13,53 12,37

This puzzle does not have any ligands.

This puzzle has a single chain.

See players' solutions from previous visits this puzzle:

Complete series of revisits with top scores:

puzzle closed top solo score top solo top evo score top evo top group score top group comments
88: Monocyte 10/01/08 9,350 Steven Pletsch 9,366 Steven Pletsch 9,366 Another Hour Another Point
818: Revisiting Puzzle 88: Monocyte 12/11/13 9,632 Ch Garnier 9,669 Bruno Kestemont 9,669 L'Alliance Francophone
1130b: Revisiting Puzzle 88: Monocyte 09/02/15 9,185 frood66 9,203 Blipperman 9,203 Gargleblasters extended due to server outage
1340: Revisiting Puzzle 88: Monocyte 02/07/17 9,520 gitwut 9,517 Bletchley Park 9,520 Contenders
1343: Revisiting Puzzle 88 with Density: Monocyte 02/17/17 11,716 tokens 11,720 Galaxie 11,720 Anthropic Dreams
1604: Revisiting Puzzle 88: Monocyte 12/05/18 10,527 Aubade01 10,521 smilingone 10,521 Beta Folders
1786: Revisiting Puzzle 88: Monocyte 01/14/20 10,603 Aubade01 10,574 silent gene 10,574 Go Science
2063: Revisiting Puzzle 88: Monocyte 11/04/21 10,486 frood66 10,487 jausmh 10,487 Marvin's Bunch