While the protein in this puzzle is from a giant green anemone (Anthopleura xanthogrammica), it's a relatively small protein. The protein can function as both a pheromone, and a toxin. The toxin is called anthropleurin or AP after the anemone's family name. The toxin affects heart activity, stimulating heart contractions at low doses without affecting heart rate or blood pressure. This effect makes the toxin interesting as the possible basis of a new treatment for heart failure.
The puzzle protein has 49 segments with the sequence:
This sequence is found in this Protein Data Bank entry:
- 1AHL (chains A, offset 0)
The puzzle protein can have three disulfide bridges, identified in 1AHL as 4-46, 6-36, and 29-47.
The recipe Bridge Wiggle v 1.2.1 - Brow42 accepts the bridges in this format:
4,46 6,36 29,47
This puzzle does not have any ligands.
This puzzle has a single chain.
See players' solutions from previous visits this puzzle:
Complete series of revisits with top scores:
|puzzle||closed||top solo score||top solo||top evo score||top evo||top group score||top group||comments|
|84: Giant Anemone||09/22/08||8,641||Steven Pletsch||8,661||g_s||8,661||Another Hour Another Point|
|806: Revisiting Puzzle 84: Giant Anemone||11/13/13||8,948||dembones||8,955||mirp||8,955||Go Science|
|1119: Revisiting Puzzle 84: Giant Anemone||08/04/15||9,236||viosca||9,227||Galaxie||9,236||Anthropic Dreams|
|1327: Revisiting Puzzle 84: Giant Anemone||01/18/17||9,339||gitwut||9,334||gitwut||9,339||Contenders|
|1593: Revisiting Puzzle 84: Giant Anemone||11/05/18||9,881||tyler0911||9,885||Galaxie||9,885||Anthropic Dreams|
|1774: Revisiting Puzzle 84: Giant Anemone||12/25/19||9,833||Aubade01||9,833||Silent Gene||9,833||Go Science|