The protein in this puzzle is calcicludine. Like many of the revisiting puzzle proteins, it's from a toxin, which is found in the venom of the green mamba. It's known to act on heart and brain cells in rats, but the exact mechanism is not fully understood.
The protein has 60 segments with the sequence:
This sequence is found in these Protein Data Bank entries:
The protein can have three disulfide bridges, identified in 1BF0 as 7-57, 16-40, and 32-53. In recent visits to this puzzle, each bridge is awarded a bonus of 250 points.
The recipe Bridge Wiggle v 1.2.1 - Brow42 accepts the bridges in this format:
7,57 16,40 32,53
This puzzle does not have any ligands.
This puzzle has a single chain.
See players' solutions from previous visits this puzzle:
Complete series of revisits with top scores:
|puzzle||closed||top solo score||top solo||top evo score||top evo||top group score||top group||comments|
|80: Calcium Channel Blocker||09/10/08||9,048||Huzar||9,086||g_s||9,086||Another Hour Another Point|
|797: Revisiting Puzzle 80: Calcium Channel Blocker||10/16/13||9,254||Hanto_FZ140E_4G||9,249||Hanto_FZ140E_4G||9,254||Clear The Way|
|1107: Revisiting Puzzle 80: Calcium Channel Blocker||07/07/15||9,463||retiredmichael||9,484||smilingone||9,484||Beta Folders|
|1314: Revisiting Puzzle 80: Calcium Channel Blocker||12/13/16||9,560||dembones||9,570||Bletchley Park||9,570||Contenders|
|1575: Revisiting Puzzle 80: Calcium Channel Blocker||09/26/18||10,112||hpaege||10,101||jausmh||10,101||Marvin's Bunch|
|1762: Revisiting Puzzle 80: Calcium Channel Blocker||11/27/19||10,346||Timo van der Laan||10,305||LociOiling||10,346||Void Crushers|