The protein in this puzzle is an antifreeze protein (AFP), which cold water fishes use to keep from freezing. This protein is from a type of fish known as an eelpout, specifically an ocean pout, Zoarces americanus.
The same protein also appears in the Ice Binding series of revisiting puzzles.
The antifreeze AFPs are not be confused with alpha-fetoprotein, also known as AFP.
The puzzle has 66 segments with the sequence:
This sequence is found in the following Protein Data Bank entry:
- 1B7I (chain A, offset 0)
There are also other PDB entries which match 65 out of 66 segments:
In 1AME and 5C7R, the mismatch is at segment 62 of the Foldit protein. In both cases, the arginine (R) at segment 62 is lysine (K) in the PDB protein.
This puzzle does not have disulfide bridges.
This puzzle does not have any ligands.
This puzzle has a single chain.
See players' solutions from previous visits to this puzzle:
Complete series of revisits with top scores:
|puzzle||closed||top solo score||top solo||top evo score||top evo||top group score||top group||comments|
|75: Antifreeze Protein||08/28/08||9,567||Franco1947||9,572||gla||9,572||Void Crushers|
|777: Revisiting Puzzle 75: Antifreeze Protein||09/18/13||9,640||Wilm||9,640||gloverd||9,640||Go Science|
|1095: Revisiting Puzzle 75: Antifreeze Protein||06/08/15||8,596||BitSpawn||8,585||mimi||8,596||Contenders|
|1298: Revisiting Puzzle 75: Antifreeze Protein||10/26/16||9,001||markm457||9,009||Galaxie||9,009||Anthropic Dreams|
|1300: Revisiting Puzzle 75 with Density: Antifreeze Protein||11/02/16||12,709||markm457||12,710||gauchomurphy||12,710||Anthropic Dreams|
|1562: Revisiting Puzzle 75: Antifreeze Protein||08/22/18||10,181||matosfran||10,181||matosfran||10,181||Beta Folders||hat trick matosfran|
|1750: Revisiting Puzzle 75: Antifreeze Protein||08/22/18||10,176||Bruno Kestemont||10,170||Bruno Kestemont||10,173||Go Science||hat trick Bruno K.|