Bruno Kestemont's histone from puzzle 1281.
70: Nucleosome Protein is a revisiting puzzle, originally presented in 2008 as Puzzle 70: Nucleosome Protein.
This protein is a histone, and has been studied extensively. Histones are responsible for keeping DNA organized.
The puzzle has 98 segments with the sequence:
phryrpgtvalreirryqkstellirklpfqrlvreiaqdfktdlrfqssavmalqeaseaylvalfedtnlcaihakrvtimpkdiqlarrirgera
PDB 4XZQ shows the Puzzle 70 protein in complex structure that includes 7 other protein chains and 2 DNA chains in a double helix. The double helix in turn spirals around the protein complex.
This sequence is found in the following Protein Data Bank entries:
- 1AOI (chains A and E, offset 18)
- 1F66 (chains A and E, offset 38)
- 1KX3 (chains A and E, offset 37)
- 1KX4 (chains A and E, offset 37)
- 1KX5 (chains A and E, offset 37)
- 1M18 (chains A and E, offset 37)
- 1M19 (chains A and E, offset 37)
- 1M1A (chains A and E, offset 37)
- 1P3B (chains A and E, offset 37)
- 1P3F (chains A and E, offset 37)
- 1P3G (chains A and E, offset 37)
- 1P3I (chains A and E, offset 37)
- 1P3O (chains A and E, offset 37)
- 1P3P (chains A and E, offset 37)
- 1S32 (chains A and E, offset 37)
- 1ZBB (chains A and E, offset 37)
- 2FJ7 (chains A and E, offset 37)
- 2NZD (chains A and E, offset 37)
- 3B6F (chains A and E, offset 37)
- 3B6G (chains A and E, offset 37)
- 3C1B (chains A and E, offset 37)
- 3KUY (chains A and E, offset 37)
- 3LEL (chains A, E, K, and O, offset 38)
- 3LJA (chains A and E, offset 37)
- 3LZ0 (chains A and E, offset 37)
- 3LZ1 (chains A and E, offset 37)
- 3MGP (chains A and E, offset 37)
- 3MGQ (chains A and E, offset 37)
- 3MGR (chains A and E, offset 37)
- 3MGS (chains A and E, offset 37)
- 3MNN (chains A and E, offset 37)
- 3MVD (chains A and E, offset 37)
- 3O62 (chains A and E, offset 37)
- 3REH (chains A and E, offset 37)
- 3REI (chains A and E, offset 37)
- 3REJ (chains A and E, offset 37)
- 3REK (chains A and E, offset 37)
- 3REL (chains A and E, offset 37)
- 3TU4 (chains A and E, offset 37)
- 3UT9 (chains A and E, offset 37)
- 3UTA (chains A and E, offset 37)
- 3UTB (chains A and E, offset 37)
- 4J8U (chains A and E, offset 37)
- 4J8V (chains A and E, offset 37)
- 4J8W (chains A and E, offset 37)
- 4J8X (chains A and E, offset 37)
- 4R8P (chains A and E, offset 37)
- 4WU8 (chains A and E, offset 37)
- 4WU9 (chains A and E, offset 37)
- 4XUJ (chains A and E, offset 37)
- 4XZQ (chains A and E, offset 0)
- 4YS3 (chains A and E, offset 0)
- 4Z66 (chains A and E, offset 0)
- 4ZUX (chains A, E, K, and O, offset 38)
- 5CP6 (chains A and E, offset 37)
- 5DNM (chains A and E, offset 37)
- 5DNN (chains A and E, offset 37)
- 5E5A (chains A and E, offset 38)
- 5HQ2 (chain A, offset 37)
- 5NL0 (chains A, E, and K, offset 37)
- 5O9G (chains A and E, offset 38)
- 5OXV (chains A, E, K, and O, offset 37)
- 5OY7 (chains A, C, E, I, M, Q, U, and Y, offset 37)
- 5XF6 (chains A and E, offset 37)
- 6ESF (chains A and E, offset 37)
- 6ESG (chains A and E, offset 37)
- 6ESH (chains A and E, offset 37)
- 6ESI (chains A and E, offset 37)
This puzzle does not have any disulfide bridges.
This puzzle does not have any ligands.
This puzzle has a single chain.
See players' solutions from previous visits to this puzzle: