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Galaxie's halorhodopsin from puzzle 1262.

62: Halorhodopsin is a revisiting puzzle, originally presented in 2009 as Puzzle 62: Halorhodopsin.

Halorhodopsin is a type of rhoposin, a light-sensitive protein. Halorhodopsin is found in single-celled organisms known as archaea, where it serves to pump chloride ions through the cell membrane.

The puzzle has 239 segments with the sequence:

 renallssslwvnvalagiailvfvymgrtirpgrprliwgatlmiplvsissylgllsgltvgmiempaghalagemvrsqwgryltwalstpmillalglladvdlgslftviaadigmcvtglaaamttsallfrwafyaiscaffvvvlsalvtdwaasassagtaeifdtlrvltvvlwlgypivwavgveglalvqsvgatswaysvldvfakyvfafillrwvannertvav

This sequence is found in the Protein Data Bank as 1E12. The puzzle sequence is at offset 2 of the sequence for chain A in 1E12. The model for 1E12 starts with residue 24, which corresponds to segment 1 of the puzzle.

Several other PDB entries are close matches, including 5G36, 5AHY, 5AHZ, 2JAF, and 2JAB, all of which differ from the puzzle sequence by only one residue.

This puzzle does not have any disulfide bridges.

This puzzle does not have any ligands.

This puzzle has a single chain.

See players' solutions from previous visits to this puzzle:

Complete series of revisits with top scores:

puzzle closed top solo score top solo top evo score top evo top group score top group comments
62: Halorhodopsin 07/03/08 13,748 gla 13,748 Void Crushers
726: Revisiting Puzzle 62 (Halorhodopsin) 06/12/13 13,651 gdnskye 13,669 Galaxie 13,669 Anthropic Dreams
1060: Revisiting Puzzle 62: Halorhodopsin 03/12/15 10,408 reefyrob 10,437 LociOiling 10,437 Beta Folders
1262: Revisiting Puzzle 62: Halorhodopsin 07/27/16 12,104 Galaxie 12,109 Galaxie 12,109 Anthropic Dreams
1514: Revisiting Puzzle 62: Halorhodopsin 05/07/18 15,585 Galaxie 15,581 Galaxie 15,585 Anthropic Dreams
1553: Sketchbook Puzzle - Revisiting Puzzle 62: Halorhodopsin 08/01/18 15,357 hpaege 15,298 toshiue 15,309 Go Science
1705: Revisiting Puzzle 62: Halorhodopsin 08/05/19 15,601 LociOiling 15,628 LociOiling 15,628 Beta Folders
1981: Revisiting Puzzle 62: Halorhodopsin 04/22/21 15,571 LociOiling 15,572 LociOiling 15,572 Beta Folders
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