The puzzle comments indicate this protein "binds to the cytoplasmic domain of the T-cell receptor", explaining the "TCR binding" in the name. The puzzle protein is a type of signaling protein that plays a role in regulating the immune system.
The puzzle has 62 segments with the sequence:
Protein Data Bank matches for this sequence:
- 1GYF (chain A, offset 0)
- 1L2Z (chain A, offset 0)
- 1SYx (chains B, D, F; offset -24)
- 4BWS (chains C, F; offset -9)
This puzzle does not have any disulfide bridges.
This puzzle does not have any ligands.
This puzzle has a single chain.
See players' solutions from previous visits to this puzzle:
Complete series of revisits with top scores:
|puzzle||closed||top solo score||top solo||top evo score||top evo||top group score||top group||comments|
|59: TCR Binding Protein||06/12/08||9,409||sirenbrian||9,409||Another Hour Another Point|
|729: Revisiting Puzzle 59: TCR Binding Protein||06/29/13||9,471||dembones||9,506||gloverd||9,506||Go Science|
|1050: Revisiting Puzzle 59: TCR Binding Protein||02/19/15||8,898||BitSpawn||8,890||viosca||8,898||Anthropic Dreams|
|1253: Revisiting Puzzle 59: TCR Binding Protein||07/06/16||9,089||Fetztastic||9,090||Paulo Roque||9,090||Go Science|
|1506: Revisiting Puzzle 59: TCR Binding Protein||04/16/18||10,156||actiasluna||10,151||ManVsYard||10,156||Gargleblasters|
|1696: Revisiting Puzzle 59: TCR Binding Protein||07/15/19||10,136||grogar7||10,117||Galaxie||10,117||Anthropic Dreams|