The puzzle protein is an enzyme, a type of phosphotransferase, specifically a kinase. This human protein is encoded by a gene known as FYN, and controls cell growth. It interacts with a long list of other proteins. Overexpression of this protein has been linked to several forms of cancer.
The puzzle has 59 segments with the sequence:
Protein Data Bank matches for this sequence:
- 1A0N (chain B, offset 4)
- 1AZG (chain B, offset 2)
- 1FYN (chain A, offset 3)
- 1G83 (chains A, B; offset 2)
- 1M27 (chain C, offset 0)
- 1NYF (chain A, offset 2)
- 1NYG (chain A, offset 2)
- 1SHF (chain B, offset 0)
- 1ZBJ (chain A, offset 0)
- 3UA6 (chains A, B; offset 4)
- 3UA7 (chains A, B, C, D; offset 4)
- 3UF4 (chain A, offset 3)
- 4EIK (chain A, offset 4)
The puzzle represents the SH3 domain of the protein.
This puzzle does not have any disulfide bridges.
This puzzle does not have any ligands.
This puzzle has a single chain.
See players' solutions from previous visits to this puzzle:
Complete series of revisits with top scores:
|puzzle||closed||top solo score||top solo||top evo score||top evo||top group score||top group||comments|
|54: Human Fyn 2||05/19/08||9,218||Rusty||9,218||Gnome Sciences|
|704: Revisiting Puzzle 54 (Human Fyn 2)||05/01/13||9,595||hansvandenhof||9,615||martinzblavy||9,615||Contenders|
|1038: Revisiting Puzzle 54: Human Fyn||01/22/15||8,892||LociOiling||8,890||reefyrob||8,892||Beta Folders|
|1241: Revisiting Puzzle 54: Human Fyn||06/08/16||9,060||LociOiling||9,103||smilingone||9,103||Beta Folders|
|1492: Revisiting Puzzle 54: Human Fyn||03/13/18||9,112||LociOiling||9,112||LociOiling||9,112||Beta Folders|
|1685: Revisiting Puzzle 54: Human Fyn||06/10/19||10,119||LociOiling||10,050||LociOiling||10,119||Beta Folders|