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Irc 476462 1421947334 S1 LociOiling

LociOiling's phosphotransferase from puzzle 1038.

54: Human Fyn 2 is a revisiting puzzle, originally presented in 2009 as Puzzle 54: Human Fyn 2.

The puzzle protein is an enzyme, a type of phosphotransferase, specifically a kinase. This human protein is encoded by a gene known as FYN, and controls cell growth. It interacts with a long list of other proteins. Overexpression of this protein has been linked to several forms of cancer.

The puzzle has 59 segments with the sequence:

vtlfvalydyearteddlsfhkgekfqilnssegdwwearslttgetgyipsnyvapvd 

Protein Data Bank matches for this sequence:

  • 1A0N (chain B, offset 4)
  • 1AZG (chain B, offset 2)
  • 1FYN (chain A, offset 3)
  • 1G83 (chains A, B; offset 2)
  • 1M27 (chain C, offset 0)
  • 1NYF (chain A, offset 2)
  • 1NYG (chain A, offset 2)
  • 1SHF (chain B, offset 0)
  • 1ZBJ (chain A, offset 0)
  • 3UA6 (chains A, B; offset 4)
  • 3UA7 (chains A, B, C, D; offset 4)
  • 3UF4 (chain A, offset 3)
  • 4EIK (chain A, offset 4)

The puzzle represents the SH3 domain of the protein.

This puzzle does not have any disulfide bridges.

This puzzle does not have any ligands.

This puzzle has a single chain.

See players' solutions from previous visits to this puzzle:

Complete series of revisits with top scores:

puzzle closed top solo score top solo top evo score top evo top group score top group comments
54: Human Fyn 2 05/19/08 9,218 Rusty 9,218 Gnome Sciences
704: Revisiting Puzzle 54 (Human Fyn 2) 05/01/13 9,595 hansvandenhof 9,615 martinzblavy 9,615 Contenders
1038: Revisiting Puzzle 54: Human Fyn 01/22/15 8,892 LociOiling 8,890 reefyrob 8,892 Beta Folders
1241: Revisiting Puzzle 54: Human Fyn 06/08/16 9,060 LociOiling 9,103 smilingone 9,103 Beta Folders
1492: Revisiting Puzzle 54: Human Fyn 03/13/18 9,112 LociOiling 9,112 LociOiling 9,112 Beta Folders
1685: Revisiting Puzzle 54: Human Fyn 06/10/19 10,119 LociOiling 10,050 LociOiling 10,119 Beta Folders
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