LociOiling's dihydrofolate reductase from puzzle 1461.

143: Rosetta Decoy 7 is a revisiting puzzle, originally presented as 143: Rosetta Decoy 7 in 2009.

This puzzle was the seventh in a series of 15 Rosetta decoys, which invited Foldit players to correct decoys produced through Rosetta, including the Rosetta@Home program.

The puzzle protein has been solved, and is identified as dihydrofolate reductase, an enzyme that helps bacteria resist certain antibiotics, among other functions.

The puzzle protein has 56 segments with the sequence:

atfgmgdrvrkksgaawqgqivgwyctnltpegyaveseahpgsvqiypvaaleri

This sequence is found in these Protein Data Bank entries:

  • 1VIE (chain A, offset 5)
  • 1VIF (chain A, offset 5)
  • 2GQV (chain A, offset 5)
  • 2RH2 (chain A, offset 5)
  • 2RK1 (chain A, offset 5)
  • 2RK2 (chain A, offset 5)
  • 3SFM (chain A, offset 5)

The puzzle protein does not form disulfide bridges.

This puzzle does not have any ligands.

This puzzle has a single chain.

See players' solutions from previous visits to this puzzle:

Complete series of revisits with top scores:

puzzle closed top solo score top solo top evo score top evo top group score top group comments
143: Rosetta Decoy 7 05/13/09 9,270 Steven Pletsch 9,278 csohad 9,278 Another Hour Another Point
1009: Revisiting Puzzle 143: Rosetta Decoy 7 11/12/14 8,568 retiredmichael 8,565 Galaxie 8,568 Beta Folders
1210: Revisiting Puzzle 143: Rosetta Decoy 7 03/30/16 8,912 LociOiling 8,949 smilingone 8,949 Beta Folders
1461: Revisiting Puzzle 143: Rosetta Decoy 7 12/26/17 8,927 LociOiling 8,926 LociOiling 8,927 Beta Folders
1919: Revisiting Puzzle 143: Rosetta Decoy 7 11/26/20 9,846 LociOiling 9,848 LociOiling 9,848 Beta Folders
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