The puzzle protein has been solved, and is identified as a component of neocarzinostatin, a substance produced by bacteria of the Streptomyces family. Neocarzinostatin is considered an "antitumor antiobiotic", and can be used in chemotherapy to treat certain forms of cancer.
Neocarzinostatin consists of a protein and a non-protein ligand known as a chromophore. The chromophore is not present in the Foldit puzzle. The protein portion of neocarzinostatin protects the unstable chromophore, releasing it under the right conditions. Once released, the chromophore can break up strands of DNA.
The puzzle protein has 112 segments with the sequence:
This sequence is found in theseProtein Data Bank entries:
The puzzle protein can have one disulfide bridge, identified in 2CBM a as 38-93. Recent revisits to this puzzle have awarded a bonus of 250 for each bridge formed.
The recipe Bridge Wiggle v 1.2.1 - Brow42 accepts the bridge in this format:
This puzzle does not have any ligands.
This puzzle has a single chain.
See players' solutions from previous visits to this puzzle:
Complete series of revisits with top scores:
|puzzle||closed||top solo score||top solo||top evo score||top evo||top group score||top group||comments|
|142: Rosetta Decoy 6||05/08/09||10,830||justjustin||10,822||tim300cx5||10,830||Another Hour Another Point|
|1006: Revisiting Puzzle 142: Rosetta Decoy 6||11/06/14||9,636||BitSpawn||9,637||gmn||9,637||Anthropic Dreams|
|1207: Revisiting Puzzle 142: Rosetta Decoy 6||03/23/16||10,251||LociOiling||10,250||smilingone||10,251||Beta Folders|
|1459: Revisiting Puzzle 142: Rosetta Decoy 6||12/19/17||10,244||Bruno Kestemont||10,247||LociOiling||10,247||Beta Folders|
|1917: Revisiting Puzzle 142: Rosetta Decoy 6||11/20/20||12,035||LociOiling||12,044||LociOiling||12,044||Beta Folders|