Foldit Wiki

actiasluna's echistatin from puzzle 1415.

Cell adhesion is a revisiting puzzle, originally presented as Puzzle 136: Cell Adhesion in 2009.

(See Cell Adhesion Protein for the similarly-named revisiting series based on Puzzle 85.)

Keeping with theme of toxins found in revisiting puzzles, the puzzle protein is a disintegrin, one of a family of proteins found in viper venoms. As the name "disintegrin" suggests, this protein actually works against cell adhesion, specifically inhibiting blood clotting.

This particular disintegrin is known as an echistatin, based on genus of the source viper, Echis carinatus sochureki, or Sochurek's saw-scaled viper.

The puzzle protein has 49 segments with the sequence:


This sequence is found in these Protein Data Bank entries:

  • 1RO3 (chain A, offset 0)
  • 2ECH (chain A, offset 0)

The puzzle protein can have four disulfide bridges, identified in 1RO3 and 2ECH as 2-11, 7-32, 8-37, and 20-39. In recent visits to this puzzle, each bridge is awarded a bonus of 250 points.

The recipe Bridge Wiggle v 1.2.1 - Brow42 accepts the bridges in this format:

2,11 7,32 8,37 20,39 

This puzzle does not have any ligands.

This puzzle has a single chain.

See players' solutions from previous visits this puzzle:

puzzle closed top solo score top solo top evo score top evo top group score top group comments
136: Cell Adhesion 04/21/09 8,842 steveB 8,785 g_s 8,785 Another Hour Another Point
1189: Revisiting Puzzle 136: Cell Adhesion 02/10/16 9,583 retiredmichael 9,586 Blipperman 9,586 Gargleblasters
1415: Revisiting Puzzle 136: Cell Adhesion 08/17/17 9,824 Glen B 9,560 actiasluna 9,570 Contenders
1442: Sketchbook Puzzle - Revisiting Puzzle 136 10/27/17 8,642 crpainter 8,645 Hollinas 8,645 Go Science sketchbook
1674: Revisiting Puzzle 136: Cell Adhesion 05/21/19 10,028 jobo0502 9,976 nicobul 10,028 L'Alliance Francophone
1890: Revisiting Puzzle 136: Cell Adhesion 09/18/20 9,950 Bruno Kestemont 9,957 Bruno Kestemont 9,957 Go Science Hat trick!
Puzzle 2134: Revisiting Puzzle 136: Cell Adhesion 04/21/22 10,063 LociOiling 10,077 Galaxie 10,077 Anthropic Dreams