The protein in this puzzle is a ubiquitin. Ubiquitin is a very common or "ubiquitous" protein, found in animals and plants (eukaryotes). Despite the name of the puzzle, ubiquitin is not limited to members of the cow family (Bovidae). The name "bovine" (or more properly, "bovid"), might be a clue about the version of the protein found in the puzzle.
Ubiquitin attaches to other proteins, and performs functions such as marking a protein for destruction by a cell's proteasome.
The puzzle protein has 70 segments with the sequence:
Ubiquitin has been widely studied, so there are hundreds of entries in the Protein Data Bank that exactly match the sequence shown above. In many cases, the PDB entry shows ubiquitin in a complex with another molecule.
The following PDB entry shows two ubiquitins (a dimer), and specifically mentions Bos taurus (a "bovine") as the source organism:
- 1AAR (chains A,B; offset 0)
The puzzle protein does not form disulfide bridges.
This puzzle does not have any ligands.
This puzzle has a single chain.
See players' solutions from previous visits this puzzle:
Complete series of revisits with top scores:
|puzzle||closed||top solo score||top solo||top evo score||top evo||top group score||top group||comments|
|112: Bovine||12/10/08||10,044||xiando||10,069||Mike Cassidy||10,069||Void Crushers||ubiquitin|
|862: Revisiting Puzzle 112: Bovine||03/26/14||9,171||auntdeen||9,174||Galaxie||9,174||Anthropic Dreams|
|1161: Revisiting Puzzle 112: Bovine||12/02/15||9,245||Bruno Kestemont||9,246||mirp||9,246||Go Science|
|1382: Revisiting Puzzle 112: Bovine||06/01/17||9,243||bertro||9,247||LociOiling||9,247||Beta Folders|
|1645: Revisiting Puzzle 112: Bovine||03/13/19||10,690||Bruno Kestemont||10,691||LociOiling||10,691||Beta Folders|
|1827: Revisiting Puzzle 112: Bovine||04/24/20||10,681||LociOiling||10,682||Angus||10,682||Beta Folders|