The protein in this puzzle is from Cucurbita maxima, a species which includes many types of pumpkins and squashes. The protein is a trypsin inhibitor, which blocks the enzyme trypsin. Trypsin breaks down proteins. Trypsin inhibitors in general can interfere with digestion of proteins, but the puzzle protein has a specific inhibitory effect on human blood coagulation factor beta-factor XIIa.
The puzzle protein has 44 segments with the sequence:
This sequence is found in this Protein Data Bank entries:
This puzzle does not have any ligands.
This puzzle has a single chain.
See players' solutions from previous visits this puzzle:
Complete series of revisits with top scores:
|puzzle||closed||top solo score||top solo||top evo score||top evo||top group score||top group||comments|
|109: Pumpkin||12/01/08||8,986||MellyLam||8,934||Rhyslarm||8,986||Another Hour Another Point|
|850: Revisiting Puzzle 109: Pumpkin||03/05/14||8,821||smilingone||8,822||LociOiling||8,822||Beta Folders|
|1154: Revisiting Puzzle 109: Pumpkin||11/11/15||8,538||WarpSpeed||8,534||O Seki To||8,534||Hun-Magyar Csapat|
|1374: Revisiting Puzzle 109: Pumpkin||05/04/17||8,626||gitwut||8,624||georg137||8,626||Contenders|
|1636: Revisiting Puzzle 109: Pumpkin||02/20/19||9,250||gdnskye||9,253||Galaxie||9,253||Anthropic Dreams|
|1816: Revisiting Puzzle 109: Pumpkin||04/01/20||9,246||Galaxie||9,245||Galaxie||9,256||Anthropic Dreams||Hat trick, Galaxie!|
|2095: Revisiting Puzzle 109: Pumpkin||01/20/22||9,322||grogar7||9,321||Galaxie||9,322||Anthropic Dreams|