Foldit Wiki

Results from Puzzle 1662.

The wiki pages listed here show images of puzzle solutions graciously provided by top-scoring players starting with puzzle 1001. See Puzzle Results: for results from puzzles 389 to 1000.

See posting results for tips on how to post images.

On the website, see Foldit Puzzles for a complete list of puzzles, past and present.

The first Foldit puzzle closed in November 2007. Player scores are shown from Puzzle 50 in May 2008 on the Foldit website.

The Puzzle Results category lists all the puzzle results pages on the wiki.

Protein classification lists early puzzles by the SCOPe class the proteins fall into. (No longer maintained.)

Contact map tips: Contact Puzzles - managing contacts


The global COVID-19 pandemic resulted in a series of coronavirus puzzles

Spike binder design

This series of puzzles involved designing a protein to bind to a coronavirus spike protein.

Protein prediction

These puzzles involved predicting the three-dimensional structure of proteins found in the SARS-CoV-2 genome.

Anti-inflammatory design

These puzzles involved designing a protein to block the "cytokine storm" that sometimes results from COVID-19.

Designable linker

This new type of puzzle involve designing a linker protein to hold two existing coronavirus spike binders in a precise three-dimensional relationship.


Design puzzles are mutable and may be symmetry or docking types.

Monomer design

Aflatoxin design

Binder design

Integrin agonist binder design

IL-7R binder design

Influenza HA Binder Design

IL-2R binder design

TGF receptor binder design

MERS-CoV binder design

The virus MERS-CoV is slosely related to SARS-CoV-2.

Two-sided interface design

These puzzles involved designing a protein to link two other proteins.

Asymmetric design

Assymetric design puzzles are less common. Like both binder design and symmetry puzzles, they feature multiple protein chains. Unlike the other puzzle types, assymmetric design puzzles involve designing both side of the interface.

By contrast, in a binder puzzle, one side of the interface is normally the target, and is mostly locked. Some of the target's sidechains may move, however.

In a symmetry puzzle, only the main chain is designable, and the symmetric chains always mirror the main chain.

Symmetry design

Dimer design

Trimer design

Tetramer design

Pentamer design

Hexamer design

Small Molecule Design

See small molecule design puzzle for more on this type of puzzle.

Electron Density

See electron density puzzle for more on this type of puzzle.


De-novo or "freestyle" puzzles generally involve "unsolved" proteins. Scientists often discover the primary structure of a protein in DNA, but aren't able to analyze the protein in the lab for various reasons. Many de-novo puzzles involve this type of mystery protein.

Some recent de-novos have actually involved proteins that were created in Foldit design puzzles. This is another way to evaluate the quality of a design. Players should be able to fold a designed protein into something close to its original designed shape.


Standard puzzles are often 'revisiting' puzzles to assist with calibration.

Each of the puzzles in the revisiting series has its own page, which includes the top score for each visit. The revisiting puzzle master list has the complete set.

CASP refinement targets

The rise of machine learning means Foldit no longer participates in the biennial CASP competition.

CASP still offers "refinement targets", predicted structures that may need work. Larger targets may be out of reach, but some smaller targets are suitable for Foldit.