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Puzzle 389 is at:

The puzzle started on 12/15/2010 and ended on 12/21/2010

"In this interface design puzzle there is a loop at the interface which is designable, try to improve the interface!"

It was a design puzzle without a ligand. Interestingly, it had constraints that would appear in red but were not marked as conditions of the puzzle.

The top score was 10,213 (evolver score by anthunk).

Several people kindly posted screenshots of their top solutions:

Evolver solutions:

Solo solutions:

  • Top solo score of 10,196 by Enzyme