Puzzle 1675: Integrin Antagonist Binder Design: Round 3

This series of puzzles designs an antagonist of integrin alpha-v/beta-3. Most of the biologically relevant information is in the first puzzle: https://fold.it/portal/node/2007672.

The core RGD motif vtprgdwne is locked in all three puzzles. PDB 4MMZ (fibronectin; paper) is an example of a semi-natural antagonist with the motif. Some manganese ions are found in the structure; they prefer to interact with H-bond acceptors.

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