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The new interface introduced in November 2021 builds on the old selection interface, and eliminates the original interface.

In this interface, the action bar contains icons for various tools, such as shake, wiggle, and mutate. Unlike the selection interface, these icons are always shown, although some tools require a selection or bands to be present.

The icons also contain keyboard shortcuts for the tools. In some cases, the shortcuts are different than in the original interface. For example, the original interface uses M for "mutate all". In the new interface, the shortcut Y is used to mutate either all segments or only selected segments. The new interface uses the shortcut M to mutate segments to a specific amino acid, a function of design mode in the original interface.

The image shows a typical set of action bar icons in the new interface.

A typical view of the action bar in the new interface.

The exact location of the icons may change when the Foldit window is resized. Also, puzzles may show different sets of icons, depending on the puzzle type.

At least two tools display additional icons when selected. The M "mutate specific" tool displays icons for the available amino acids. The L "modify secondary structure" tool displays icons for the structure types, plus an icon for the auto structures tool. Both these tools also display a "back arrow" icon (shortcut B), which cancels the tool without making any changes.

Lowercase letters are used for the default tool shortcuts. For example, the shortcut for wiggle is shown as "W", but the user would actually type "w" to activate the tool.

Shortcuts can be modified in General Options menu, under Controls -> Configure Keyboard Shortcuts. At least in the initial release, changing a shortcut in this way does not change the shortcut code in tool's icon. Also, there appear to be problems remapping some shortcuts, such as M "mutate specific".

Many of the tools either operate all on all segments or selected segments. For example, W "wiggle" wiggles all segments if nothing is selected, or else it wiggles only selected segments.

Clicking on a segment selects it, or de-selects an already selected segment. Selecting a segment, then shift-clicking another segment selects a range of segments. Control-clicking (cmd-click on Mac) can be used to fine-tune a selection containing multiple segments.

Some tool icons are grayed out in certain conditions. The conditions for each tool are:

  • 4 - Remix - three to nine contiguous segments selected with no open cutpoints
  • 0 - Rebuild - one or more segments selected
  • 2 - Idealize peptide bonds - two or more segments selected
  • C - Create cutpoints - two adjacent segments selected
  • A - Pick sidechains - one or more segments selected
  • 1 - Display/hide notes - one or more notes present
  • R - Remove bands - one or more bands present
  • D - Disable/enable bands - one or more bands present
  • L - Modify secondary structure - one or more segments selected
  • 5 - Idealize secondary structure - one or more segments selected
  • X - Delete segments - one or more segments selected
  • I - Insert segments - one or two adjacent segments selected
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