Try to complete each puzzle without help first. Most of the puzzles should take only a couple of minutes. If you get stuck, use "Reset Puzzle" from the Actions menu in the lower left and try again.
Note: the video QUICK Foldit Tutorial Walkthrough from S0ckrates shows you how to be the boss of the intro puzzles.
If you're having problems, you'll find tips below. Just click on the icon for the puzzle you're stuck on. There are tips and techniques for each puzzle, and Foldit players have contributed YouTube videos for most of the puzzles.
If you have additional questions, ask online in the Foldit client using "Chat - Global", or "Chat - Group". See Foldit chat for more on Foldit chat. The following translations of this page are available: Deutsch | Svenska | Español | German | Russian | Japanese.
The campaign puzzles are arranged in levels. Each level covers a different part of Foldit. You earn a Foldit achievement when you complete a level.
There are different paths through the levels. The paths may allow you to move on to a new level if you get stuck on a particular puzzle. You can always come back later to finish a problem puzzle.
Click on the icons below for more information about each intro puzzle. The Intro Puzzle Master List has the same information in a simplified format.
The Backbone Packing level introduces the backbone, the part which holds the protein together. The sidechains are attached to the backbone.
The Hydrogen Bonding level introduces hydrogen bonds, which help hold proteins together. Hydrogen bonds show as blue-and-white "candy canes" in Foldit.
Hydrophobics and Hydrophilics
This level digs itno hydrophobics and hydrophilics in more detail. Orange sidechains are hydrophobic, and should be hidden on the inside of the protein. Blue sidechains are hydrophilic, and are OK on the outside of the protein.
This level introduces Foldit design puzzles, which give players the chance to design new proteins. Some of these designs actually get turned into real proteins in the Foldit lab, see design puzzle results for more.
This level covers conditions, which enforce special rules on some puzzles. Conditions may change your score, adding or subtracting points. Conditions were previously called "filters".
This level introduces the blueprint tool, which is used in design puzzles to insert shapes found in natural proteins. The blueprint tool may help players create proteins which fold up on their own like natural ones. Design puzzles are covered in more detail in the next section.
Tools and Types
The Tools and Types level introduces some of the different puzzle types found in Foldit. The move tool is added.
This level also introduces the remix tool, which searches for new shapes for your protein.
Sequences introduces the alignment tool. The alignment tool lets you apply the shapes of other proteins to the protein you're working on.
You'll also get to use cuts, which chop a protein into pieces. Cuts are used in all kinds of ways in Foldit.
The More Molecules level introduces ligands. A ligand is a non-protein atom or molecule. A ligand can be as small as copper or calcium atom, or as large as a strand of DNA.
These puzzles work with fixed ligands that can't be changed. A new small molecule design feature is in development for Foldit. This will allow the ligand to be designed, much as current designs puzzles allow proteins to be designed.