An article published in Nature Scientific Reports in 2018 describing Foldit's role in the WeFold collaboration in CASP 10 and 11.

Foldit in the newsEdit

General scienceEdit

The contribution of Foldit players to Scientific ResultsEdit

All Foldit players participate in a scientific investigation. Whatever their contribution (from folding to giving feedbacks or giving tips to other or sharing intermediate solutions). As "citizen scientist", they contribute directly to some mass data collections on likely protein structures (from a mass of results, top scoring solutions are analyzed as the best promising, but also "shared to scientists" ones and even low scoring ones for statistical analyses). They are also observed as players and/or citizen scientists. From this point of view, they are themselves "objects of science" They are the objects of social or technical studies on "gamification", games, social sciences, human/machine interface, artificial intelligence etc. Aside of pure fun in competition, "contributing to Science" has been reported as one of the highest motivation of Foldit players. The contribution of Foldit players is often acknowledged by the researchers in their blogs and science chats, as well as by many authors who quote Foldit as a famous example of complex and difficult "serious game" or "game with purpose". But very high level scientific visible results are rare enough to be quoted here. The papers bellow are papers where Foldit players contributed significantly to Scientific advances, either as co-authors or as "co-subjects" of studies that have reached high level scientific publications.

  • Chen Keasar, Liam J. McGuffin, Björn Wallner, Gaurav Chopra, Badri Adhikari, Debswapna Bhattacharya, Lauren Blake, Leandro Oliveira Bortot, Renzhi Cao, B. K. Dhanasekaran, Itzhel Dimas, Rodrigo Antonio Faccioli, Eshel Faraggi, Robert Ganzynkowicz, Sambit Ghosh, Soma Ghosh, Artur Giełdoń, Lukasz Golon, Yi He, Lim Heo, Jie Hou, Main Khan, Firas Khatib, George A. Khoury, Chris Kieslich, David E. Kim, Pawel Krupa, Gyu Rie Lee, Hongbo Li, Jilong Li, Agnieszka Lipska, Adam Liwo, Ali Hassan A. Maghrabi, Milot Mirdita, Shokoufeh Mirzaei, Magdalena A. Mozolewska, Melis Onel, Sergey Ovchinnikov, Anand Shah, Utkarsh Shah, Tomer Sidi, Adam K. Sieradzan, Magdalena Ślusarz, Rafal Ślusarz, James Smadbeck, Phanourios Tamamis, Nicholas Trieber, Tomasz Wirecki, Yanping Yin, Yang Zhang, Jaume Bacardit, Maciej Baranowski, Nicholas Chapman, Seth Cooper, Alexandre Defelicibus, Jeff Flatten, Brian Koepnick, Zoran Popović, Bartlomiej Zaborowski, David Baker, Jianlin Cheng, Cezary Czaplewski, Alexandre Cláudio Botazzo Delbem, Christodoulos Floudas, Andrzej Kloczkowski, Stanislaw Ołdziej, Michael Levitt, Harold Scheraga, Chaok Seok, Johannes Söding, Saraswathi Vishveshwara, Dong Xu & Foldit Players consortium (Ahmet Caglar, Alan Coral, Alison MacMillan, Allen Lubow, Barbara Failer, Bruno Kestemont, Catherine R. Landers, Charles Robert Painter, Christophe Garnier, Claudine Sellin, Dietmar Janz, Douglas Craig Wheeler, Vera Simon, Dylan M. Flear, Emmanuel Croze, George Victor McIlvaine, Gil Beecher, Gordon Lawrie, Guy Ykman, Harald Feldmann, Heidemarie K. Fuentes, Hosokawa Terumasa, Istvan Kovanecz, James Absalom Longino III, Jan Hendrik Nijland, Jasper A. Diderich, Jeffrey M. Canfield, Jesper Eriksson, Jesse David Slone, Joan Goldsworthy Appel, Joanne Mitchell, John Mitch, Jorn Loots-Boiy, June M. Brownlee, Karsten Wilson, Keith T. Clayton, Kenneth E. DeFord, Kirk J. Abbey, Larry Withers, Linda Wei, Lloyd Ives, Lori A. Miller, Lynn Carpenter, Manasa G. Sharma, Manuel Ricci, Mark Stewart Binfield, Matthew John Davids, Matthias Gaebel, Michael D. Cassidy, Michael Fagiola, Michael Pfützenreuter, Nova Barlow, Peter John Triggiani IV, Renton Braden Mathew Innes, Robert Leduc, Rodrigo Luccas Corrêa dos Santos Gomes, Rosemarie L. R. Morneau, Scott J. Zaccanelli, Susan C. Kleinfelter, T. J. A. van der Laan, Thomas Bausewein, Thomas J. George, Varichev Mikhail & Walter Barmettler) & Silvia N. Crivell. An analysis and evaluation of the WeFold collaborative for protein structure prediction and its pipelines in CASP11 and CASP12. Nature Scientific Reports volume 8, Article number: 9939 (2018)
  • Scott Horowitz, Brian Koepnick, Raoul Martin, Agnes Tymieniecki, Amanda A. Winburn, Seth Cooper, Jeff Flatten, David S. Rogawski, Nicole M. Koropatkin, Tsinatkeab T. Hailu, Neha Jain, Philipp Koldewey, Logan S. Ahlstrom, Matthew R. Chapman, Andrew P. Sikkema, Meredith A. Skiba, Finn P. Maloney, Felix R. M. Beinlich, Foldit Players, University of Michigan students, Zoran Popović, David Baker, Firas Khatib & James C. A. Bardwell. Determining crystal structures through crowdsourcing and coursework. Nature Communications 7, Article number: 12549 (2016), doi:10.1038/ncomms12549
  • George A. Khoury, Adam Liwo, Firas Khatib, Hongyi Zhou, Gaurav Chopra, Jaume Bacardit, Leandro O. Bortot, Rodrigo A. Faccioli, Xin Deng, Yi He, Pawel Krupa, Jilong Li, Magdalena A. Mozolewska, Adam K. Sieradzan, James Smadbeck, Tomasz Wirecki, Seth Cooper, Jeff Flatten, Kefan Xu, David Baker, Jianlin Cheng, Alexandre C. B. Delbem, Christodoulos A. Floudas, Chen Keasar, Michael Levitt, Zoran Popović, Harold A. Scheraga, Jeffrey Skolnick, Silvia N. Crivelli and Foldit Players. WeFold: a coopetition for protein structure prediction. Proteins (2014).
  • Firas Khatib, Seth Cooper, Michael D. Tyka, Kefan Xu, Ilya Makedon, Zoran Popović, David Baker and Foldit Players. Algorithm discovery by protein folding game players. Proceedings of the National Academy of Sciences of the United States of America (2011).
  • Seth Cooper, Adrien Treuille, Janos Barbero, Andrew Leaver-Fay, Kathleen Tuite, Firas Khatib, Alex Cho Snyder, Michael Beenen, David Salesin, David Baker, Zoran Popović and Foldit players. The challenge of designing scientific discovery games. Proceedings of the 5th International Conference on the Foundations of Digital Games (2010).
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