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(how much longer, Catalina)
(Latest puzzle info.)
 
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Foldit is an online game in which humans try to solve one of the hardest computational problems in biology: protein folding. You don't need to know anything about biology to play the game, although a little background will help. Most Foldit player are not biologists. Read about [http://fold.it/portal/info/science The Science Behind Foldit].
 
Foldit is an online game in which humans try to solve one of the hardest computational problems in biology: protein folding. You don't need to know anything about biology to play the game, although a little background will help. Most Foldit player are not biologists. Read about [http://fold.it/portal/info/science The Science Behind Foldit].
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{{HeadingB|Coronavirus!}}
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In response to the global pandemic, Foldit has been coronavirus puzzles of various types.
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The puzzles so far have involved designing binder proteins to attach to the [[Coronavirus Spike Protein|coronavirus spike protein]], designing anti-inflammatory proteins to calm the "cytokine storm" sometimes triggered by the virus, and predicting the 3D structure of proteins the virus is believed to manufacture, with names like NSP2, NSP6, and ORF3a.
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There will probably be coronavirus puzzles running for the foreseeable future, see [https://fold.it/portal/puzzles the official list of puzzles] for details.
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See the [[Coronavirus FAQ]] for general information about the Foldit coronavirus puzzles.
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{{HeadingB|New Players}}
 
{{HeadingB|New Players}}
 
Visit the [http://fold.it/portal/ fold.it, the official Foldit site] to download the game and get started. Foldit runs on Windows, Mac, and 64-bit Linux. See [[Download-Install-Troubleshoot]] for install instructions. Use the [http://fold.it/portal/feedback feedback page] if you're having trouble getting the game installed. If you're seeing "error contacting server" messages, update [http://fold.it/portal/node/2004768#comment-36310 this feedback] with details.
 
Visit the [http://fold.it/portal/ fold.it, the official Foldit site] to download the game and get started. Foldit runs on Windows, Mac, and 64-bit Linux. See [[Download-Install-Troubleshoot]] for install instructions. Use the [http://fold.it/portal/feedback feedback page] if you're having trouble getting the game installed. If you're seeing "error contacting server" messages, update [http://fold.it/portal/node/2004768#comment-36310 this feedback] with details.
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The [[Intro Puzzles]] show you the tools, try them before trying a science puzzle. [[Tutorial Puzzles (deutsch)| (deutsch)]] | [[Tutorial Puzzles (svenska)| (svenska)]]
 
The [[Intro Puzzles]] show you the tools, try them before trying a science puzzle. [[Tutorial Puzzles (deutsch)| (deutsch)]] | [[Tutorial Puzzles (svenska)| (svenska)]]
   
See [[Get Started Playing Foldit]] for more.
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The video [https://www.youtube.com/watch?v=bIc-FoHLtjY QUICK Foldit Tutorial Walkthrough] from S0ckrates shows the fast path through the intro puzzles.
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See [[Get Started Playing Foldit]] for more background.
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Foldit's [[Education mode|education mode]] features a series of puzzles that go into much more technical depth than the regular intro puzzles. (Education mode involves installing a separate version of Foldit, see [https://fold.it/educator For Educators] on the Foldit web site.)
   
 
Please read the Foldit [http://fold.it/portal/guidelines Community Guidelines] and [http://fold.it/portal/legal Terms of Service].
 
Please read the Foldit [http://fold.it/portal/guidelines Community Guidelines] and [http://fold.it/portal/legal Terms of Service].
   
 
See [[Foldit Status]] for any issues affecting the game.
 
See [[Foldit Status]] for any issues affecting the game.
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{{HeadingB|What's folding}}
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Note: this list gets updated weekly after the last puzzle expires. See [https://fold.it/portal/puzzles the official list of puzzles] for the most current puzzle info.
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*[https://fold.it/portal/node/2010341 Puzzle 1891: Symmetric Trimer Design: H-bond Networks], expires 23 September 2020.
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*[https://fold.it/portal/node/2010344 Puzzle 1892: Coronavirus Binder Design: Round 18], expires 24 September 2020. It's accompanied by the [[devprev]] puzzle [https://fold.it/portal/node/2010345 Sandbox Puzzle 1892 with Binder Metrics], which lets players see the [[binder metrics]] for their designs.
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*[https://fold.it/portal/node/2010313 Puzzle 1890: Revisiting Puzzle 136: Cell Adhesion], expires 25 September 2020.
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*[https://fold.it/portal/node/2010259 LCB1 Coronavirus Spike Binder], expires 30 September 2020. This sandbox puzzle awards no points.
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*As always, there are [[Intro Puzzles]] to get started, and then [[Beginner puzzle|Beginner Puzzles]] which allow players to hone their skills.
 
{{HeadingB|Updates}}
 
{{HeadingB|Updates}}
*Hacks for Macs: as [https://fold.it/portal/user/461359 bkoep] mentions in the [https://www.youtube.com/watch?v=TrdHN21wwNc&feature=youtu.be Foldit Lab Report #2] on YouTube, the Catalina version of MacOS means no more 32-bit clients. A fresh download and install of the Mac 64-bit client is needed. See [https://fold.it/portal/node/2008244 Transferring Foldit Data] (thanks again, bkoep) for tips on how to copy your settings and more to the new setup. ([[Foldit file and directory structure]] and [[Manual update]] here on the wiki may also be of interest for those who tinker.)
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*Objective oriented: the new [[DDG]], [[SASA]], and [[Shape complementarity|shape complementarity]] objectives are now part of the main update group. The Foldit team is still trying to streamline these metrics, so at the moment, you'll only see them in [[devprev]] "shadow" puzzles.
*Pet symmitry: just in time for Halloween, the [[Devprev|devprev]] release allows banding to the symmetric chains in a [[Symmetry puzzle|symmetry puzzle]]. The new function [[Foldit_Lua_Function_structure.GetSymCount|structure.GetSymCount]] detects how many symmetric chains are available. A value of zero means it's not a symmetry puzzle. The function [[Foldit_Lua_Function_band.AddBetweenSegments|band.AddBetweenSegments]] now allows the band's endpoint to be on one of the symmetric copies.
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*No revisiting: a series of CASP refinement puzzles has interrupted the normal revisiting puzzles. These puzzles present one or more [[CASP]] "solutions" to a protein. The real solutions , determined experimentally, haven't been published yet. The CASP solutions are a poor match. Foldit players once again get a chance to show up the scientists by finding a better solution.
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*[[Discord]] comes to Foldit: A new [https://discord.gg/Ffgx2KJ Discord server] gives players a new spot to hang out. Discord is oriented toward online gaming, and offers many features not found in IRC chat. In addition to basic text chat, Discord has voice chat and even screen sharing options. Discord has apps for Windows, macOS, Android, and iOS, and also offers web access. Discord users can be connected on multiple platforms at the same time. Messages on Discord persist, so offline users can catch up later.
  +
*Deep thoughts: a Foldit blog post describes the upcoming [https://fold.it/portal/node/2010076 energy landscape optimization paper] and provides a link to the pre-print version. Foldit players have a chance to be [https://fold.it/portal/node/2010013 listed by name] in this paper, a gracious concession from the robot overlords.
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*DOTM: [https://fold.it/portal/node/2010093 Design of the Month: August 2020] lets players tinker with a design NinjaGreg created on [[Puzzle 1864]]. This puzzle awards no points, but lets players see a successful design in full detail. Players can try to refine the design, or start over with a new design. As the name implies, the puzzle runs for the month of August.
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*Chillin': the [https://fold.it/portal/node/2008272 Foldit Cryo-EM paper] has been published in PLOS Biology. The Foldit blog makes you scroll down before announcing '''Foldit players take gold!'''. Once again, Foldit players beat actual scientists. The [https://doi.org/10.1371/journal.pbio.3000472.s029 paper's supplement (docx format)] contains commentary from several Foldit players on how they did it.
 
*Free proteins: the four known [[Solved Foldit designs|solved Foldit designs]] seen in the [[Foldit protein design paper]] are now available in all their 3D glory in the [[PDB]].
 
*Free proteins: the four known [[Solved Foldit designs|solved Foldit designs]] seen in the [[Foldit protein design paper]] are now available in all their 3D glory in the [[PDB]].
 
*Nurture versus Nature: [https://www.nature.com/articles/s41586-019-1274-4 De novo protein design by citizen scientists], describing the results of Foldit design puzzles, was published in '''Nature''' 5 June 2019. Five Foldit players are listed as named authors, along with "Foldit Players". A longer list of players appears in the "Supplementary information" section. See the [https://fold.it/portal/node/2007798 Foldit blog post] about the paper. Congratulations to lead author Brian Koepnick!
 
*Nurture versus Nature: [https://www.nature.com/articles/s41586-019-1274-4 De novo protein design by citizen scientists], describing the results of Foldit design puzzles, was published in '''Nature''' 5 June 2019. Five Foldit players are listed as named authors, along with "Foldit Players". A longer list of players appears in the "Supplementary information" section. See the [https://fold.it/portal/node/2007798 Foldit blog post] about the paper. Congratulations to lead author Brian Koepnick!
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[[File:Foldit_1583469164_trimmed.jpg|thumb|300px|Image credit: silent gene]]
[[File:wisky_tand_contenders.png]]
 
 
Players can submit screenshots of their best or most interesting results using the camera button in chat. The Foldit wiki has thousands of these images. See [[Puzzle_Results_1|recent puzzle results]] and [[Puzzle_Results|older results]] for a complete list. See [[Posting results|posting results]] for tips on how to post.<br>
 
Players can submit screenshots of their best or most interesting results using the camera button in chat. The Foldit wiki has thousands of these images. See [[Puzzle_Results_1|recent puzzle results]] and [[Puzzle_Results|older results]] for a complete list. See [[Posting results|posting results]] for tips on how to post.<br>
 
{{HeadingB|The Science}}
 
{{HeadingB|The Science}}

Latest revision as of 22:50, September 18, 2020

Foldit is an online game in which humans try to solve one of the hardest computational problems in biology: protein folding. You don't need to know anything about biology to play the game, although a little background will help. Most Foldit player are not biologists. Read about The Science Behind Foldit.

Coronavirus!

In response to the global pandemic, Foldit has been coronavirus puzzles of various types.

The puzzles so far have involved designing binder proteins to attach to the coronavirus spike protein, designing anti-inflammatory proteins to calm the "cytokine storm" sometimes triggered by the virus, and predicting the 3D structure of proteins the virus is believed to manufacture, with names like NSP2, NSP6, and ORF3a.

There will probably be coronavirus puzzles running for the foreseeable future, see the official list of puzzles for details.

See the Coronavirus FAQ for general information about the Foldit coronavirus puzzles.

New Players

Visit the fold.it, the official Foldit site to download the game and get started. Foldit runs on Windows, Mac, and 64-bit Linux. See Download-Install-Troubleshoot for install instructions. Use the feedback page if you're having trouble getting the game installed. If you're seeing "error contacting server" messages, update this feedback with details.

The Intro Puzzles show you the tools, try them before trying a science puzzle. (deutsch) | (svenska)

The video QUICK Foldit Tutorial Walkthrough from S0ckrates shows the fast path through the intro puzzles.

See Get Started Playing Foldit for more background.

Foldit's education mode features a series of puzzles that go into much more technical depth than the regular intro puzzles. (Education mode involves installing a separate version of Foldit, see For Educators on the Foldit web site.)

Please read the Foldit Community Guidelines and Terms of Service.

See Foldit Status for any issues affecting the game.

What's folding

Note: this list gets updated weekly after the last puzzle expires. See the official list of puzzles for the most current puzzle info.

Updates

  • Objective oriented: the new DDG, SASA, and shape complementarity objectives are now part of the main update group. The Foldit team is still trying to streamline these metrics, so at the moment, you'll only see them in devprev "shadow" puzzles.
  • No revisiting: a series of CASP refinement puzzles has interrupted the normal revisiting puzzles. These puzzles present one or more CASP "solutions" to a protein. The real solutions , determined experimentally, haven't been published yet. The CASP solutions are a poor match. Foldit players once again get a chance to show up the scientists by finding a better solution.
  • Discord comes to Foldit: A new Discord server gives players a new spot to hang out. Discord is oriented toward online gaming, and offers many features not found in IRC chat. In addition to basic text chat, Discord has voice chat and even screen sharing options. Discord has apps for Windows, macOS, Android, and iOS, and also offers web access. Discord users can be connected on multiple platforms at the same time. Messages on Discord persist, so offline users can catch up later.
  • Deep thoughts: a Foldit blog post describes the upcoming energy landscape optimization paper and provides a link to the pre-print version. Foldit players have a chance to be listed by name in this paper, a gracious concession from the robot overlords.
  • DOTM: Design of the Month: August 2020 lets players tinker with a design NinjaGreg created on Puzzle 1864. This puzzle awards no points, but lets players see a successful design in full detail. Players can try to refine the design, or start over with a new design. As the name implies, the puzzle runs for the month of August.
  • Chillin': the Foldit Cryo-EM paper has been published in PLOS Biology. The Foldit blog makes you scroll down before announcing Foldit players take gold!. Once again, Foldit players beat actual scientists. The paper's supplement (docx format) contains commentary from several Foldit players on how they did it.
  • Free proteins: the four known solved Foldit designs seen in the Foldit protein design paper are now available in all their 3D glory in the PDB.
  • Nurture versus Nature: De novo protein design by citizen scientists, describing the results of Foldit design puzzles, was published in Nature 5 June 2019. Five Foldit players are listed as named authors, along with "Foldit Players". A longer list of players appears in the "Supplementary information" section. See the Foldit blog post about the paper. Congratulations to lead author Brian Koepnick!
  • Closely contested: Foldit now lets you bring your own protein with custom contests. This feature has been frequently requested for classroom puzzles. We'll have more about it on the wiki soon, in the mean time read the paper describing how it works.
  • Naming names: a number of Foldit players are listed as authors (using their real names) on an article just published in Nature Scientific Reports. See Interesting Articles (under "contribution of Foldit players to scientific results") for a complete list and a link to the paper.

Videos

David Baker (U

David Baker (U. Washington HHMI) Crowd Sourcing Protein Folding Rosetta@Home and FoldIt


Tools, tips, techniques

Several translations of the Foldit Wiki are available:
FlaggeDE German FlaggeItalien Italian Nihon-Japan-25Japanese 25px-Flag of South Korea Korean FlagRussia Russian FlagSpain Spanish France-25 French

Featured articles

Contents   ( View All Pages - Foldit Wikia Index )

Foldit 1583469164 trimmed

Image credit: silent gene

Players can submit screenshots of their best or most interesting results using the camera button in chat. The Foldit wiki has thousands of these images. See recent puzzle results and older results for a complete list. See posting results for tips on how to post.

The Science

These pages describe the science of protein folding.


Helping out

This is a wiki about the Foldit game that anyone can edit. Before you do edit it, however, please take a look around and determine whether or not the article you'd like to write already exists. (If it does exist, feel free to make it better!)

To write a new article, just enter the article title in the box below.

Not sure where to start?
Adding content
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Community content is available under CC-BY-SA unless otherwise noted.