Foldit is an online citizen science game in which humans try to solve one of the hardest computational problems in biology: protein folding. You don't need to know anything about biology to play the game, although a little background will help. Most Foldit player are not biologists. Read about The Science Behind Foldit.
New Players
Visit the fold.it, the official Foldit site to download the game and get started. Foldit runs on Windows, Mac (64-bit), and 64-bit Linux (64-bit). See Download-Install-Troubleshoot for install instructions. Use the feedback page if you're having trouble getting the game installed. If you're seeing "error contacting server" messages, update this feedback with details.
The Intro Puzzles show you the tools, try them before trying a science puzzle. (deutsch) | (svenska)
The video QUICK Foldit Tutorial Walkthrough from S0ckrates shows the fast path through the intro puzzles.
See Get Started Playing Foldit for more background.
Foldit's education mode features a series of puzzles that go into much more technical depth than the regular intro puzzles. (Education mode involves installing a separate version of Foldit, see For Educators on the Foldit web site.)
Please read the Foldit Community Guidelines and Terms of Service. Please also see the Rules of the Foldit wiki.
See Foldit Status for any issues affecting the game.
What's folding
Note: this list gets updated weekly after the last puzzle expires. See the official list of puzzles for the most current puzzle info.
- Puzzle 2005b: IL-2R Binder Design: Round 1, expires 18 June 2021.
- Puzzle 2006: Symmetric D2 Tetramer Design: Limited Interface, expires 23 June 2021.
- Puzzle 2007: Large Electron Density Transcription factor, expires 24 June 2021. This large electron density has 235 segments, and is marked "advanced". In Foldit, it's somewhat hidden, you'll find it after the Design of the Month and the Protein Design Sandbox puzzles in the list.
- Puzzle 2008: TGF Receptor Binder Design: Round 6, expires 25 June 2021.
- Design of the Month: June 2021, expires 30 June 2021. This sandbox puzzle awards no points, but challenges players to improve on a TGF binder design by Foldit player toshiue from Puzzle 1985. See Foldit Lab Report #21 for more.
- As always, there are Intro Puzzles to get started, and then Beginner Puzzles which allow players to hone their skills.
Updates
- Coming attractions: the new Foldit website should be available soon, according to an "office hour" chat with Foldit developer jflat06 on 18 April 2021. The new website includes a new recipe management system, which replaces the old cookbook. As previously announced, older GUI and Lua V1 recipes will no longer work once the new website is completed. According to jflat06, the new site will likely be available in preview mode before that happens.
- Discord comes to Foldit: A new Discord server gives players a new spot to hang out. Discord is oriented toward online gaming, and offers many features not found in IRC chat. In addition to basic text chat, Discord has voice chat and even screen sharing options. Discord has apps for Windows, macOS, Android, and iOS, and also offers web access. Discord users can be connected on multiple platforms at the same time. Messages on Discord persist, so offline users can catch up later.
- Chillin': the Foldit Cryo-EM paper has been published in PLOS Biology. The Foldit blog makes you scroll down before announcing Foldit players take gold!. Once again, Foldit players beat actual scientists. The paper's supplement (docx format) contains commentary from several Foldit players on how they did it.
- Nurture versus Nature: De novo protein design by citizen scientists, describing the results of Foldit design puzzles, was published in Nature 5 June 2019. Five Foldit players are listed as named authors, along with "Foldit Players". A longer list of players appears in the "Supplementary information" section. See the Foldit blog post about the paper. Congratulations to lead author Brian Koepnick!
- Naming names: a number of Foldit players are listed as authors (using their real names) on an article just published in Nature Scientific Reports. See Interesting Articles (under "contribution of Foldit players to scientific results") for a complete list and a link to the paper.
Videos
David Baker (U. Washington HHMI) Crowd Sourcing Protein Folding Rosetta@Home and FoldIt
- FolditatUW - foldit's official YouTube channel.
- P1 - Introduction to Protein Design (15m)
- P2 - Design of New Protein Functions (27m)
- Beta_Helix's Foldit video the basics explained (40m)
- Through the eyes of a scientist Design solutions reviewed (26m)
- Design solutions reviewed Part 2 (22m)
- As seen on TV: Origami Revolution. Nova on PBS featured protein folding, David Baker, Rosetta@Home and Foldit. (Minutes 20 through 28, with Foldit briefly mentioned at 23:45.)
Tools, tips, techniques
- Foldit 101 - Useful information about Puzzle Types, the Cookbook and recipe basics.
- How to get started - With pictures from an actual puzzle
- Puzzle Results - screen shots of top scoring and interesting player solutions.
- Blackbelt Folding - Sessions 1,2, 3 & 4 denovo
- Electron Density - info and videos
- Hydrogen Bond Networks
- Download-Install-Troubleshoot includes Tracks, devprev and using multiple clients on Windows, Mac and Linux
- Foldit chat (IRC)
- Frequently asked questions
- Foldit Accessibility
- Foldit Translations
Several translations of the Foldit Wiki are available:
German
Italian 
Japanese 
Korean
Russian
Spanish
French
Featured articles
- Strategy - how to improve your score
- TheGame - tools, score details and Lua scripting
- Groups-Players - groups (teams), players and a bit of humour.
- The Research Room - advanced discussions and lots of external links
- Scientist and Developer Chats
- Hydrogen Bond Networks
- Small molecule design puzzles
- Interesting Articles
Contents ( View All Pages - Foldit Wikia Index )
Image credit: silent gene
Players can submit screenshots of their best or most interesting results using the camera button in chat. The Foldit wiki has thousands of these images. See recent puzzle results and older results for a complete list. See posting results for tips on how to post.
Discord
Try Discord as an alternative to Foldit's IRC chat. Key Foldit channels like #veteran and #global are mirrored between Discord and IRC by helpful bots.
The Science
These pages describe the science of protein folding.
- Structure
- Primary Structure
- Secondary Structure
- Hydrophilic and Hydrophobic (also known as "blue out, orange in")
- Protein Folding Theory
- CASP
- Rosetta@Home
- Biochemistry I
Helping out
Please see the Foldit wiki Rules before making changes.
If you are new to Fandom wikis, check out Fandom Basics.
For minor changes (typos, spelling, grammar, etc.) please go ahead and make the change.
For more substantial changes, please join the Foldit Discord server, and introduce yourself on the #wiki channel. The #wiki channel is the best place to discuss new articles or changes to existing articles.
Please try to keep your user name/screen name the same or at least recognizable between Foldit, Discord, and Fandom. That will help prevent confusion and misunderstandings.
The Foldit wiki has a Wanted Articles page, but it's mostly broken links and other things that need to be cleaned up. The Stubs page on the Foldit wiki is normally empty, but might contain a list of articles that need content added. Foldit has been busy adding new features lately, and the wiki is still trying to catch up. At some point, the stubs/wanted articles lists might become more relevant, but right now they're not really in use.
There's also a community portal page here on the wiki, but it's never been used.
