(Drug design) Tag: rte-wysiwyg |
No edit summary Tag: rte-wysiwyg |
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[[File:Foldit Drug Design First Tutorial|thumb|right|335px|First tutorial video]] |
[[File:Foldit Drug Design First Tutorial|thumb|right|335px|First tutorial video]] |
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| + | <span style="color:rgb(100,100,106);font-family:helvetica,sans-serif;font-size:14px;line-height:normal;">During the past decade, advances in drug design (specifically structure-based drug discovery) have seen a lot of success. However, the automated tools for this are encountering a huge problem with the total chemical space that can be sampled.</span> |
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| − | Write the first paragraph of your page here. |
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| + | <span style="color:rgb(100,100,106);font-family:helvetica,sans-serif;font-size:14px;line-height:normal;">This is where you, as Foldit players, can help. The immense chemical and conformational space that needs to be sampled is greatly reduced with human spatial recognizing skills, which are far more robust at recognizing patterns than computer algorithms and can intuitively sample conformational and chemical space.</span> |
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==Introduction== |
==Introduction== |
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*[https://fold.it/portal/node/2000972 Drug design puzzles coming! - 23 Jul 2015] |
*[https://fold.it/portal/node/2000972 Drug design puzzles coming! - 23 Jul 2015] |
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*[http://fold.it/portal/node/2000238/ Drug design introduction - 22 Jan 2015] |
*[http://fold.it/portal/node/2000238/ Drug design introduction - 22 Jan 2015] |
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| − | *[https://fold.it/portal/node/2000310 Drug design Part 2 (includes video)] |
+ | *[https://fold.it/portal/node/2000310 Drug design Part 2 (includes video) 2 Feb 2015] |
| + | *[https://fold.it/portal/node/2000541 Drug design Interface Update - 25 Mar 2015] |
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Revision as of 02:19, 3 October 2015
Foldit Drug Design First Tutorial
First tutorial video
During the past decade, advances in drug design (specifically structure-based drug discovery) have seen a lot of success. However, the automated tools for this are encountering a huge problem with the total chemical space that can be sampled.
This is where you, as Foldit players, can help. The immense chemical and conformational space that needs to be sampled is greatly reduced with human spatial recognizing skills, which are far more robust at recognizing patterns than computer algorithms and can intuitively sample conformational and chemical space.
Introduction
Drug molecules (small molecules) bind to a target molecule (protein in our case) and effect the function of the protein. This change in protein function leads to the desired physiological effect of relieving disease or its symptoms.