Changes: Drug design

Latest revision as of 05:23, 4 February 2018

Foldit_Drug_Design_First_Tutorial — Foldit Drug Design First Tutorial

A short silent video shows an intro puzzle that demonstrates small molecule or drug design. This intro puzzle is not currently active.

Drug design is now known as small molecule design.

The small molecule design features have been under development in Foldit for quite a while, held back by technical problems.

The first Small molecule design puzzle was 1432: HIV Protease Inhibitor Small Molecule Design.

A series of Foldit blog posts has described the development process:

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-[[File:Foldit Drug Design First Tutorial|thumb|right|335px|First tutorial video]]
+[[File:Foldit Drug Design First Tutorial|thumb|right|335px|A short silent video shows an [[Intro Puzzles|intro puzzle]] that demonstrates small molecule or drug design. This intro puzzle is not currently active.]]
+[[Drug design]] is now known as [[Small molecule design puzzle|small molecule design]].
-<span style="color:rgb(100,100,106);font-family:helvetica,sans-serif;font-size:14px;line-height:normal;">During the past decade, advances in drug design (specifically structure-based drug discovery) have seen a lot of success. The automated tools for this are encountering a huge problem with the total chemical space that can be sampled.</span>
+The small molecule design features have been under development in Foldit for quite a while, held back by technical problems.
-<span style="color:rgb(100,100,106);font-family:helvetica,sans-serif;font-size:14px;line-height:normal;">This is where you, as Foldit players, can help. The immense chemical and conformational space that needs to be sampled is greatly reduced with human spatial recognizing skills, which are far more robust at recognizing patterns than computer algorithms and can intuitively sample conformational and chemical space.</span>
+The first [[Small molecule design puzzle]] was [http://fold.it/portal/node/2004215 1432: HIV Protease Inhibitor Small Molecule Design].
-==Introduction==
+A series of [http://fold.it/portal/blog Foldit blog] posts has described the development process:
-<span style="color:rgb(51,51,51);font-family:helvetica,sans-serif;font-size:12px;line-height:normal;">Drug molecules (small molecules) bind to a target molecule (protein in our case) and effect the function of the protein. This change in protein function leads to the desired physiological effect of relieving disease or its symptoms.</span>
-==Drug Design links==
 *[http://fold.it/portal/node/2000238/ Drug design introduction - 22 Jan 2015]
-*[https://fold.it/portal/node/2000310 Drug design Part 2 (includes video) 2 Feb 2015]
+*[https://fold.it/portal/node/2000310 Drug design Part - 2 Feb 2015]
 *[https://fold.it/portal/node/2000541 Drug design Interface Update - 25 Mar 2015]
 *[https://fold.it/portal/node/2000972 Drug design puzzles coming! - 23 Jul 2015]
-*[http://fold.it/portal/node/2001237 Lets get ready for drug design! - 30 Oct 2015]
+*[http://fold.it/portal/node/2001237 Let's get ready for drug design! - 30 Oct 2015]
+*[http://fold.it/portal/node/2001560 Devprev Drug Design Update - 4 Dec 2015]
+*[http://fold.it/portal/node/2002358 Drug Design Update: Tool Talk - 26 April 2016]
+*[http://fold.it/portal/node/2002407 Drug Design Update: Merk Molecular Force Field - 3 May 2016]
+*[http://fold.it/portal/node/2002464 Big Update: Experimental Client (Drug Design) - 18 May 2016]
+*[http://fold.it/portal/node/2004219 Introducing Small Molecule Design Puzzles - 19 Sept 2017]
+[[Category:Biochemistry]]
+[[Category:Glossary]]