Select Design Mode, then click on one of the light-colored segments. Select one of the large hydrophobic amino acids from the orange outer ring of the mutate wheel. (Cheat: tryptophan (TRP or W) is the largest sidechain out there.)
As in the previous puzzle, wiggle is not available, but shake is. Try some different mutations, and see what impact they have on the voids and the score.
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Next: Mass Mutate
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