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(Mostly correcting grammar from the translations. Also copied the intro from the CASP9 page) |
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| + | Critical Assessment of Protein Structure Prediction (CASP) is a experiment held every two years to assess the state of protein folding. In this contest-style teams are divided into two groups, those with human intervention, and those that are completely automated. FoldIt entries will be entered as the "human" type. These puzzles are completely blind, in that the structure of the proteins in question have never been published. Labs from around the world each try to find the best solution for each puzzle. |
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| − | '''''''CASP (Critical Assessment of Techniques for Protein Structure Prediction'''''; dt.: ''critical review of techniques for protein structure prediction) is a community experiment that takes place biennially since 1994 (often referred to as a competitive ),[...].'' |
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''CASP provides research groups the opportunity to improve the quality of their methods to predict protein structures based test of the primary structure and an overview of the current status of this research.'' |
''CASP provides research groups the opportunity to improve the quality of their methods to predict protein structures based test of the primary structure and an overview of the current status of this research.'' |
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| − | These protein structures are not yet published as a guideline used for the calculations and compared the results of the calculations, then with experimental laboratory results. |
+ | These protein structures are not yet published as a guideline used for the calculations and compared the results of the calculations, then with experimental laboratory results. |
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| − | (Excerpt from the German [http://de.wikipedia.org/wiki/CASP [http://de.wikipedia.org/wiki/CASP Wikipedia-Artikel]]) |
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Current Timeline: |
Current Timeline: |
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* New targets will be posted as they come in. |
* New targets will be posted as they come in. |
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The rolling experiment will run all year round. |
The rolling experiment will run all year round. |
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During the regular CASP10 prediction season (May-August, 2012) the targets that are estimated to be in the appropriate difficulty category will be posted to both experiments. |
During the regular CASP10 prediction season (May-August, 2012) the targets that are estimated to be in the appropriate difficulty category will be posted to both experiments. |
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== CASP10 == |
== CASP10 == |
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| − | CASP10 http://predictioncenter.org/casp10/index.cgi |
+ | CASP10 web page: http://predictioncenter.org/casp10/index.cgi |
Current Timeline: |
Current Timeline: |
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With mini-CASP-puzzle, the tertiary structure, which is the duration of the individual puzzle still unknown, announced |
With mini-CASP-puzzle, the tertiary structure, which is the duration of the individual puzzle still unknown, announced |
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shortly after. You have to do anything with the CASP competition, but are used by Foldit team and the players to prepare for it. |
shortly after. You have to do anything with the CASP competition, but are used by Foldit team and the players to prepare for it. |
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== CASP9 == |
== CASP9 == |
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| + | Information from [[CASP 9]] is on its own page. |
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| − | [[CASP_9]] |
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== CASP8 == |
== CASP8 == |
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| − | Foldit was the first time |
+ | Foldit was represented for the first time at the eighth competition (CASP8) which took place during 2008, but in that competition FoldIt results were part of the BakerLab CASP team. In preparation the players had folded old CASP7 proteins and compared the results from the developers with the published structures. |
| − | + | The first open beta of FoldIt was released a few days after the start of CASP8<ref>http://www.predictioncenter.org/news.cgi#15</ref>. The players and developers then spent a month training and developing the program further before trying their hand at their first CASP8 puzzle<ref>http://fold.it/portal/node/273682</ref>. As a result, they were only involved in relatively few competition targets. Despite these handicaps the FoldIt team did well with some top places and even a victory! Overall, the Foldit players were as good as the experts with all their tools and better than any automated machine submissions<ref>http://fold.it/portal/node/729520</ref>. |
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Revision as of 09:23, 3 December 2011
Critical Assessment of Protein Structure Prediction (CASP) is a experiment held every two years to assess the state of protein folding. In this contest-style teams are divided into two groups, those with human intervention, and those that are completely automated. FoldIt entries will be entered as the "human" type. These puzzles are completely blind, in that the structure of the proteins in question have never been published. Labs from around the world each try to find the best solution for each puzzle.
CASP provides research groups the opportunity to improve the quality of their methods to predict protein structures based test of the primary structure and an overview of the current status of this research.
These protein structures are not yet published as a guideline used for the calculations and compared the results of the calculations, then with experimental laboratory results.
CASP Roll Information
CASP Roll web page: http://predictioncenter.org/casprol/index.cgi
Current Timeline:
- First prediction targets will be released not earlier than December 1, 2011
- Second target is expected December 2, 2011
- Further targets are expected in the following week
- New targets will be posted as they come in.
The rolling experiment will run all year round.
During the regular CASP10 prediction season (May-August, 2012) the targets that are estimated to be in the appropriate difficulty category will be posted to both experiments.
CASP10
CASP10 web page: http://predictioncenter.org/casp10/index.cgi
Current Timeline:
- The first prediction targets will be released not earlier than May 1, 2012
- the last prediction targets will be released not later than July 17, 2012
- prediction season will end not later than July 31, 2012
- Refinement experiment will end not later than August 17, 2012
- Abstracts describing the methods tested in CASP10 will be collected in September 2012
- Program of the meeting will be available in November, 2012
- In November 2012, groups with the most accurate predictions and interesting methods will receive invitations to give talks.
- The meeting will take place on December 9-12, 2012
Mini-CASP
With mini-CASP-puzzle, the tertiary structure, which is the duration of the individual puzzle still unknown, announced shortly after. You have to do anything with the CASP competition, but are used by Foldit team and the players to prepare for it.
CASP9
Information from CASP 9 is on its own page.
CASP8
Foldit was represented for the first time at the eighth competition (CASP8) which took place during 2008, but in that competition FoldIt results were part of the BakerLab CASP team. In preparation the players had folded old CASP7 proteins and compared the results from the developers with the published structures.
The first open beta of FoldIt was released a few days after the start of CASP8[1]. The players and developers then spent a month training and developing the program further before trying their hand at their first CASP8 puzzle[2]. As a result, they were only involved in relatively few competition targets. Despite these handicaps the FoldIt team did well with some top places and even a victory! Overall, the Foldit players were as good as the experts with all their tools and better than any automated machine submissions[3].
Literature
Building the Scientific - bild der wissenschaft edition: 4 / 2010, page 18 - Perfectly shaped - Article on Protein Structure Prediction and CASP