Foldit Wiki
Register
(Add CASP 11)
Line 4: Line 4:
   
 
In this contest-style teams are divided into two groups, those with human intervention, and those that are completely automated. FoldIt entries will be entered as the "human" type. These puzzles are completely blind, in that the structure of the proteins in question have never been published.
 
In this contest-style teams are divided into two groups, those with human intervention, and those that are completely automated. FoldIt entries will be entered as the "human" type. These puzzles are completely blind, in that the structure of the proteins in question have never been published.
  +
==CASP 11 (2014)==
 
   
 
== CASP Roll ==
 
== CASP Roll ==

Revision as of 05:17, 22 December 2014

CASP, which stands for Critical Assessment of Techniques for Protein Structure Prediction, is a community-wide, worldwide experiment for protein structure prediction taking place every two years since 1994. CASP provides research groups with an opportunity to objectively test their structure prediction methods and delivers an independent assessment of the state of the art in protein structure modeling to the research community and software users.

Even though the primary goal of CASP is to help advance the methods of identifying protein three-dimensional structure from its amino acid sequence, many view the experiment more as a “world championship” in this field of science. More than 100 research groups from all over the world participate in CASP on a regular basis and it is not uncommon for the entire groups to suspend their other research for months while they focus on getting their servers ready for the experiment and on performing the detailed predictions. (Information taken from the CASP page on Wikipedia: please see that page for more information on the selection and evaluation of target proteins.)

In this contest-style teams are divided into two groups, those with human intervention, and those that are completely automated. FoldIt entries will be entered as the "human" type. These puzzles are completely blind, in that the structure of the proteins in question have never been published.

CASP 11 (2014)

CASP Roll

CASP Roll web page: http://predictioncenter.org/casprol/index.cgi

The rolling experiment will run all year round.

To see the server predictions , use PyMOL , Jmol or foldit alone version.

Table of all puzzles and natives.

The result of puzzles previous to casp10 was published.

Foldit results

All Results

CASP10

CASP10 web page: http://predictioncenter.org/casp10/index.cgi

Timeline:

  • The  prediction targets are released
  • the last prediction targets have been released in July 17, 2012
  • prediction season end July 31, 2012
  • Refinement experiment end in August 17, 2012
  • Abstracts describing the methods tested in CASP10 have been collected in September 2012
  • The meeting  take place on December 9-12, 2012

see table of all puzzles

see some statitics

see some results of Foldit players

blog entries: CASP10 update (2012/09)

Group performance on all models #101 Foldit, #124 AD, #127 Contenders, #140 VC

Group performance on first model #116 Foldit, #120 VC, #123 AD, #126 Contenders

WeFold results : WeFold  wfFUIK, (Foldit participating in the WeFold CASP 10 project )

Mini-CASP

In early August of 2009, the foldit developers decided to give the players starting models outputted from Rosetta@home, by obtaining sequences for proteins that were currently unsolved, but would be released to the Protein Data Bank soon after. Since no one knew which structure predictions would be correct, they tried to give the players as diverse a set as possible.

The intent was practice for everyone for the upcoming CASP9, and to help the developers figure out what the best Rosetta models would be to use as starting points for Foldit. (taken from Dr. Baker's Mini CASP announcement http://fold.it/portal/node/986632)

CASP9

Information from CASP 9 is on its own page.

CASP8

Foldit was represented for the first time at the eighth competition (CASP8) which took place during 2008, but in that competition FoldIt results were part of the BakerLab CASP team. In preparation the players had folded old CASP7 proteins and compared the results from the developers with the published structures.

The first open beta of FoldIt was released a few days after the start of CASP8[1]. The players and developers then spent a month training and developing the program further before trying their hand at their first CASP8 puzzle[2]. As a result, they were only involved in relatively few competition targets. Despite these handicaps the FoldIt team did well with some top places and even a victory! Overall, the Foldit players were as good as the experts with all their tools and better than any automated machine submissions[3].


Literature

Building the Scientific - bild der wissenschaft edition: 4 / 2010, page 18 - Perfectly shaped - Article on Protein Structure Prediction and CASP

Sources