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Both [[Hydrophobic|hydrophobic]] and [[Hydrophilic|hydrophilic]] residues can be buried, but it's considered most important to bury as many hydrophobic residues as possible. |
Both [[Hydrophobic|hydrophobic]] and [[Hydrophilic|hydrophilic]] residues can be buried, but it's considered most important to bury as many hydrophobic residues as possible. |
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| − | When a residue is buried, it's not accessible to the [[Solvent|solvent]] inside a cell. The solvent consists mainly of water. This is the case for most protein puzzles submitted by Foldit. However, the solvent may be oily, like for membrane proteins. In this case, [[Hydrophobic|hydrophobic]] residues should be [[Exposeds|exposed]], and [[Hydrophilic|hydrophilic]] residues should be buried. Foldit rarely proposes us membrane proteins. When it's the case, like for puzzle [http://fold.it/portal/node/2003490 1347], they have to adjust the score function. The Foldit default score function favors buried hydrophobics (orange sidechains score better when buried inside). |
+ | When a residue is buried, it's not accessible to the [[Solvent|solvent]] inside a cell. The solvent consists mainly of water. This is the case for most protein puzzles submitted by Foldit. However, the solvent may be oily, like for membrane proteins. In this case, [[Hydrophobic|hydrophobic]] residues should be [[Exposeds|exposed]], and [[Hydrophilic|hydrophilic]] residues should be buried. Foldit rarely proposes us membrane proteins. When it's the case, like for puzzle [http://fold.it/portal/node/2003490 1347], they have to adjust the [[Score|score function]]. The Foldit default score function favors buried hydrophobics (orange sidechains score better when buried inside). |
[[Category:Biochemistry]] |
[[Category:Biochemistry]] |
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[[Category:Glossary]] |
[[Category:Glossary]] |
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Revision as of 15:34, 28 February 2017
In protein folding, a residue or amino acid is Buried when its sidechain is in the interior core of the protein. If a residue is on the surface of the protein, it's exposed.
In Foldit, the hiding score component reflects how well a residue is buried in the core. In general, every segment in the protein has a negative hiding score.
Both hydrophobic and hydrophilic residues can be buried, but it's considered most important to bury as many hydrophobic residues as possible.
When a residue is buried, it's not accessible to the solvent inside a cell. The solvent consists mainly of water. This is the case for most protein puzzles submitted by Foldit. However, the solvent may be oily, like for membrane proteins. In this case, hydrophobic residues should be exposed, and hydrophilic residues should be buried. Foldit rarely proposes us membrane proteins. When it's the case, like for puzzle 1347, they have to adjust the score function. The Foldit default score function favors buried hydrophobics (orange sidechains score better when buried inside).