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Foldit is an online game in which humans try to solve one of the hardest computational problems in biology: protein folding. You don't need to know anything about biology to play the game, although a little background will help. Most Foldit player are not biologists. Read about The Science Behind Foldit.

Coronavirus!

Foldit is running two types of coronavirus puzzles, and a lot of new users have joined to help in the fight.

In the first type, players try to design a binder to attach to the "spike protein" that allows coronavirus to attach to human cells. Several player designs have been selected for testing in the "wet lab", as detailed in the Foldit blog post Coronavirus binder designs queued for testing!

The coronavirus beginner puzzle that runs until 15 April 2020 also targets the spike. The beginner version starts with a design for the binder, which players can try to improve or even totally replace.

A second type of coronavirus puzzle involves helper proteins found in coronavirus. Unlike the spike protein, the 3D structure of these proteins is not known. The current intermediate puzzle Puzzle 1820: Coronavirus ORF8 Prediction is the second one of this type, and starts a de-novo puzzle, with all the amino acids in a straight extended chain.

Puzzle 1821: Coronavirus Binder Design: Round 6 starts with a coronavirus binder design created by Steven Pletsch in Puzzle 1811. Players can work to refine the Pletsch design, or start over with an entirely new design.

See the Coronavirus FAQ for general information about the Foldit coronavirus puzzles.

New Players

Visit the fold.it, the official Foldit site to download the game and get started. Foldit runs on Windows, Mac, and 64-bit Linux. See Download-Install-Troubleshoot for install instructions. Use the feedback page if you're having trouble getting the game installed. If you're seeing "error contacting server" messages, update this feedback with details.

The Intro Puzzles show you the tools, try them before trying a science puzzle. (deutsch) | (svenska)

New: the video QUICK Foldit Tutorial Walkthrough from S0ckrates shows the fast path through the intro puzzles.

See Get Started Playing Foldit for more.

Please read the Foldit Community Guidelines and Terms of Service.

See Foldit Status for any issues affecting the game.

What's folding

Updates

  • Flying down to Rio: Portuguese translation describes how to install socramdm's new Brazilian Portuguese translation. Also Foldit Translations and Translating Foldit have been revised, and there are new pages Set language and List of translations.
  • Lab work: Coronavirus binder designs queued for testing!
  • Discord comes to Foldit: A new Discord server gives players a new spot to hang out. Discord is oriented toward online gaming, and offers many features not found in IRC chat. In addition to basic text chat, Discord has voice chat and even screen sharing options. Discord has apps for Windows, macOS, Android, and iOS, and also offers web access. Discord users can be connected on multiple platforms at the same time. Messages on Discord persist, so offline users can catch up later.
  • Chillin': the Foldit Cryo-EM paper has been published in PLOS Biology. The Foldit blog makes you scroll down before announcing Foldit players take gold!. Once again, Foldit players beat actual scientists. The paper's supplement (docx format) contains commentary from several Foldit players on how they did it.
  • Free proteins: the four known solved Foldit designs seen in the Foldit protein design paper are now available in all their 3D glory in the PDB.
  • Nurture versus Nature: De novo protein design by citizen scientists, describing the results of Foldit design puzzles, was published in Nature 5 June 2019. Five Foldit players are listed as named authors, along with "Foldit Players". A longer list of players appears in the "Supplementary information" section. See the Foldit blog post about the paper. Congratulations to lead author Brian Koepnick!
  • Closely contested: Foldit now lets you bring your own protein with custom contests. This feature has been frequently requested for classroom puzzles. We'll have more about it on the wiki soon, in the mean time read the paper describing how it works.
  • Naming names: a number of Foldit players are listed as authors (using their real names) on an article just published in Nature Scientific Reports. See Interesting Articles (under "contribution of Foldit players to scientific results") for a complete list and a link to the paper.

Videos

David Baker (U

David Baker (U. Washington HHMI) Crowd Sourcing Protein Folding Rosetta@Home and FoldIt


Tools, tips, techniques

Several translations of the Foldit Wiki are available:
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Featured articles

Contents   ( View All Pages - Foldit Wikia Index )

Foldit 1583469164 trimmed

Image credit: silent gene

Players can submit screenshots of their best or most interesting results using the camera button in chat. The Foldit wiki has thousands of these images. See recent puzzle results and older results for a complete list. See posting results for tips on how to post.

The Science

These pages describe the science of protein folding.


Helping out

This is a wiki about the Foldit game that anyone can edit. Before you do edit it, however, please take a look around and determine whether or not the article you'd like to write already exists. (If it does exist, feel free to make it better!)

To write a new article, just enter the article title in the box below.

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Community content is available under CC-BY-SA unless otherwise noted.